From the USA to Africa and the UK, Stephen Fry tracks down people whose lives have been transformed by this brutal disease, including those he holds dear. Stephen meets the doctors who were instrumental in initially defining the disease, such as Professor Brian Gazzard, formerly Freddie Mercury's doctor, and Professor Michael Gottlieb, Rock Hudson's doctor. He talks to people serving jail senteces for deliberately spreading the disease, and to public figures such as writer Armistead Maupin, who are all dedicated to spreading awareness. Stephen also meets some of the earliest diagnosed people who are, miraculously, still alive. He discovers what living with HIV really means, and what the future holds for this persistent and misunderstood illness.
Each of the Moonshiners shares personal Christmas traditions, and we learn some history behind traditional Appalachian holiday celebrations. Tim celebrates holiday traditions with his firehouse family by throwing a Christmas Dinner Fundraiser at the firehouse. Josh cuts the best Christmas tree for his daughter and helps her decorate it with some homemade cookie ornaments. Mark and Jeff take part in a hog hunt to catch the main course for their big holiday dinner. Bill handcrafts some chairs for his parents Christmas gifts, and Tickle offers everyone some holiday tips.
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